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The Ameliorating Effects of Black Garlic (Allium satvium) Water Extracts on Male Reproductive Dysfunction in High-Fat Diet-Induced Obese Rats
學生姓名 : 童正華
指導教授 : 龔瑞林
學  號 : 10432045
學  期 : 105下
摘  要 : Obesity is a serious public health problem, its risk originates from disruption in adipose tissue function resulting in a chronic inflammatory state and oxidative stress. Some studies have shown a relationship between obesity and infertility. Recent studies have demonstrated that Black Garlic (Allium satvium) has the beneficial effects on obesity, but the effects of black garlic on reproductive dysfunction induced by oxidative stress and chronic inflammation has not yet been investigated. Thus, the aim of the study focuses on that whether the effects of black garlic water extracts (BGE) on improving high fat diet-induced male reproductive damage. Data showed BGE exhibited increased reducing power and antioxidant capacity with increased concentration. In animal experiment, male sprague-dawley rats were fed high-fat diet (HFD) for 5 weeks to induce obesity. BGE was tested in three doses (100, 200, 500 mg/kg per day) high-fat diet during 5 weeks. The results showed that BGE can improve plasma triglycerides, total cholesterol, leptin and testosterone level in high dose group. This study also found that the level of antioxidant enzymes were increased in high dose group; the level of inflammatory cytokine including TNF-α and IL-1β was decreased. Thus, the spermatogenesis in testes and sperm quality can be improved. In conclusion, black garlic beneficially ameliorated reproductive dysfunction via induction of oxidative stress and inflammation in HFD-induced obese rats.
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